Ophthalmic delivery device and ophthalmic drug compositions

A cannulation device for administering an active agent containing composition to an eye comprising:

• an elongated body with a hollow needle at a distal end;
• a cannula comprising an elongated tubular element with an atraumatic distal tip, where at least a portion of the tubular element is contained in a lumen of the needle prior to deployment
• a force element that provides a deployment force to advance the tubular element through the needle lumen;
• a mechanical coupling element from the force element to the tubular element either:
• i) a reservoir to contain an active agent containing composition for administration in communication with the proximal end of the tubular element;
• or
• ii) a connector or an injection port in communication with the proximal end of the tubular element for delivery of an active agent containing composition;
• a mechanism for activation of the force element prior to or simultaneous with placement of the distal tip of the needle into the eye;
• and
• a distal element attached to the distal end of the device thereby sealing or blocking the needle lumen from advancement of the tubular element out of the needle while under the deployment force;
• wherein:
• the deployment force from the force element acts to advance the tubular element out from the distal end of the needle into the suprachoroidal space or supraciliary space;
• the distal element comprises a distal seal, and wherein the distal seal acts as a tissue interface and is penetrable by a distal tip of the needle by the application of pressure on the surface of an eye with the distal end of the device;
• the penetrated distal element becomes slidable on the needle to allow advancement of the needle into tissue;
• the penetrated distal seal opens a path for advancement of the tubular element from the distal end of the needle;
• and
• the distal seal comprises deformable protrusions that extend into the lumen at the distal end of the needle or that extend into a distal projection of the lumen from the distal end that would be sufficient to prevent deployment of the tubular element under the deployment force.