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US 11,618,893 B2Granted
Anc80 encoding sphingolipid-metabolizing proteins for mitigating disease-induced tissue damage
AssigneeIcahn School of Medicine at Mount Sinai
InventorsEfrat Eliyahu, Adam Vincek, Anthony Fargnoli, Michael Katz
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Abstract
The present disclosure relates generally to the use of sphingolipid-metabolizing proteins to mitigate or minimize tissue damage resulting from injury or from disease, for example, pulmonary arterial hypertension (PAH) when the sphingolipid-metabolizing protein is delivered via expression from an Anc80 vector.
Claims10
A method of treating damage to pulmonary tissue, said method comprising:
- selecting a subject having pulmonary tissue damage resulting from pulmonary arterial hypertension and
- administering to the subject a therapeutic amount of an Anc80 viral vector comprising a polynucleotide encoding a ceramidase.
Dependencies are inferred from the claim text.