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US 11,617,814 B2Granted
Methods of treatment comprising administering polymer particles configured for intravascular delivery of pharmaceutical agents
AssigneeTerumo Kabushiki Kaisha
InventorsGregory M. Cruise, Xinping Wu, Gloria Hincapie, Yue Wu
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Abstract
Described herein are polymeric particles configured for intravascular delivery of pharmaceutical agents, e.g., to a diseased site, and methods of forming and using same. Preparation of these polymer particles is also described.
Claims18
A method of treatment comprising:
- administering a solution including a plurality of particles to a treatment site, wherein the plurality of particles include a reaction product of at least one monomer, at least one crosslinker, and at least one polymerizable pharmaceutical agent, wherein the at least one polymerizable pharmaceutical agent is chemically bonded to the particle with a hydrolytically degradable linkage;
- wherein the at least one polymerizable pharmaceutical agent has a structure
- wherein
- n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12;
- p is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12;
- R is O or NH;
- and
- R′ is H or CH3.
5 more elements
Dependencies are inferred from the claim text.