Methods for treating NLRP3 inflammasome-associated diseases, and methods of identifying agents useful therefor
AssigneeThe Regents of the University of California
InventorsMichael Karin, Zhenyu Zhong
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Abstract
Provided herein are methods of treating NLRP3 inflammasome-associated diseases and disorders. Also, disclosed are methods for screening for agents useful in such methods.
Claims9
A method of identifying an agent that inhibits Nod-like receptor pyrin domain containing 3 (NLRP3) inflammasome activation, comprising contacting a sample of cells with at least one test agent, wherein a decrease in cytidine monophosphate kinase 2 (CMPK2) activity or expression present in the sample as measured by an immunoblot assay in the presence of the test agent as compared to CMPK2 activity or expression present in the sample as measured by an immunoblot assay in the absence of the test agent identifies the agent as useful for inhibiting NLRP3 inflammasome activation.
Dependencies are inferred from the claim text.