Composition for hepatic arterial chemoembolization using human serum albumin nanoparticles carrying anticancer agent, and method for producing same
AssigneesSogang University Research Foundation, Seoul National University R&Db Foundation, Imgt Co., Ltd.
InventorsHyun Cheol Kim, Jin Wook Chung, Eun Ah Jung
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Abstract
The present invention aims to dramatically increase the effect of hepatic arterial chemoembolization by developing human serum albumin-based nanoparticles, which are bioproteins that effectively carry Adriamycin in place of Adriamycin, an anticancer agent used in hepatic arterial chemoembolization. The human serum albumin nanoparticles carrying the Adriamycin not only intensively infiltrate the drug effectively into the cells but also have a synergistic effect that can induce a long-term therapeutic effect by utilizing the effect of continuous drug release from the particles.
Claims13
A method for hepatic arterial embolization comprising:
- administering a composition comprising an effective amount of an embolic material;
- and an effective amount of human serum albumin nanoparticles carrying a water-soluble anticancer agent, to a subject having a liver tumor,
- wherein the water-soluble anticancer agent is loaded in the human serum albumin nanoparticles,
- wherein the composition is in the form of an emulsion in which the human serum albumin nanoparticles carrying a water-soluble anticancer agent are mixed with the embolic material,
- wherein a volume ratio of the embolic material to the human serum albumin nanoparticles is 3:1 to 4:1,
- wherein the human serum albumin nanoparticles have a size of 100 nm to 300 nm, and
- wherein the embolic material is an ethiodized oil.
Dependencies are inferred from the claim text.