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US 11,614,442 B2Granted
Method for determining the distinctive nutritional requirements of a patient
AssigneeSociete des Produits Nestle S.A.
InventorsSerge Andre Dominique Rezzi, Stephanie Blum-Sperisen, Magali Faure, Denis Breuille
Life of this patent
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Abstract
The present invention relates to a method for determining the distinctive nutritional requirements of a patient with specific nutritional needs and providing a composition meeting the distinctive nutritional requirements of said patient.
Claims18
A method for manufacturing a nutritional composition for administration to a subject suffering from a disease characterized by distinctive nutritional requirements in the subject over a healthy subject, the method comprising:
- a. determining in a sample of the subject suffering from the disease a profile of statuses of markers comprising direct and indirect markers indicating the nutritional profile of the subject, wherein each of the direct markers indicates an amount of a macronutrient or micronutrient, and each of the indirect markers are derived from the direct markers by quantifying a corresponding direct marker and quantifying one or more additional markers that indicate a status of the corresponding direct marker, at least one of the direct and indirect markers is selected from the group consisting of an amino acid marker, a fat marker, a carbohydrate marker, a nucleotide marker, an osmolyte marker, a peptide marker, a catabolism marker, a nitric synthase marker, and combinations thereof;
- b. determining in a sample of the healthy subject a profile of the statuses of the same markers comprising the same direct and indirect markers determined in step a, at least one of the sample of the subject suffering from the disease or the sample of the healthy subject is a sample selected from the group consisting of whole blood, blood plasma, blood serum, red blood cells, urine, tissue biopsies, and combinations thereof;
- c. comparing the profiles determined in steps a. and b., and determining distinctive nutritional requirements for nutrients comprising macronutrients and micronutrients in the subject suffering from the disease based on the comparison of the profiles determined in steps a. and b., wherein when a level of the markers determined in step a. is lower than a level of the same markers determined in step b., the distinctive nutritional requirements for the subject comprise a composition comprising the nutrients in an effective amount to enable a level of the nutrients in the subject suffering from the disease to match a level of the nutrients in the healthy subject;
- and
- d. manufacturing the composition comprising the nutrients in the effective amount to restore the nutritional profile of the nutrients in the subject suffering from the disease to or toward that of the healthy subject as determined in step b.
2 more elements
A method of treating a human subject suffering from a disease characterized by distinctive nutritional requirements in the human subject over a healthy subject, the method comprising:
- a. determining in a sample of the human subject suffering from the disease a profile of statuses of direct and indirect markers indicating the nutritional profile of the human subject, wherein each of the direct markers indicates an amount of a macronutrient or micronutrient, and each of the indirect markers are derived from the direct markers by quantifying a corresponding direct marker and quantifying one or more additional markers that indicate a status of the corresponding direct marker, at least one of the direct and indirect markers is selected from the group consisting of an amino acid marker, a fat marker, a carbohydrate marker, a nucleotide marker, an osmolyte marker, a peptide marker, a catabolism marker, a nitric synthase marker, and combinations thereof;
- b. determining in a sample of the healthy subject a profile of the statuses of the same markers comprising the same direct and indirect markers determined in step a, at least one of the sample of the subject suffering from the disease or the sample of the healthy subject is a sample selected from the group consisting of whole blood, blood plasma, blood serum, red blood cells, urine, tissue biopsies, and combinations thereof;
- c. comparing the profiles determined in step a. and b., and determining distinctive nutritional requirements for nutrients comprising macronutrients and micronutrients in the human subject suffering from the disease based on the comparison of the profiles determined in steps a. and b., wherein when a level of the markers determined in step a. is lower than a level of the same markers determined in step b., the distinctive nutritional requirements for the subject comprise a composition comprising the nutrients in an effective amount to enable a level of the nutrients in the subject suffering from the disease to match a level of the nutrients in the healthy subj ect;
- d. providing the composition to restore the nutritional profile of the nutrients in the human subject suffering from the disease;
- and
- e. administering the composition to the human subject suffering from the disease.
3 more elements
Dependencies are inferred from the claim text.