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US 11,613,770 B2Granted
Compositions and methods for making (R)-reticuline and precursors thereof
AssigneeAntheia, Inc.
InventorsPeter James Facchini, Scott Cameron Farrow, Guillaume Arthur Welch Beaudoin
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Abstract
Methods that may be used for the manufacture of the chemical compound (R)-Reticuline and synthesis precursors thereof. Compositions useful for the synthesis (R)-Reticuline and synthesis precursors are also provided.
Claims10
A method for preparing (R)-Reticuline or an (R)-Reticuline precursor, the method comprising:
- (a) introducing into a non-plant cell a chimeric nucleic acid sequence that encodes a polypeptide haying an amino acid sequence that corresponds to at least 85% of the sequence identity to the polypeptide encoded by SEQ ID NO:
- 322, comprising as operably linked components:
- (i) a first nucleic acid sequence encoding CYP450;
- (ii) a second nucleic acid sequence encoding AKR;
- and
- (iii) one or more nucleic acid sequence capable of controlling expression in a host cell;
- (b) growing the host cell to produce CYP450, AKR, and (R)-Reticuline or the (R)-Reticuline precursor.
4 more elements
Dependencies are inferred from the claim text.