Primary alcohol producing organisms
AssigneeGenomatica, Inc.
InventorsJun Sun, Anthony P. Burgard, Priti Pharkya
Life of this patent
Estimating the term…
Abstract
The invention provides a non-naturally occurring microbial organism having a microbial organism having at least one exogenous gene insertion and/or one or more gene disruptions that confer production of primary alcohols. A method for producing long chain alcohols includes culturing these non-naturally occurring microbial organisms.
Claims28
A non-naturally occurring eukaryotic organism, comprising at least two gene disruptions, said at least two gene disruptions comprise a first gene disruption occurring in a gene encoding an enzyme selected from the group consisting of a cytosolic pyruvate decarboxylase, a cytosolic ethanol-specific alcohol dehydrogenase, and a mitochondrial ethanol-specific alcohol dehydrogenase, and a second gene disruption occurring in a gene encoding an enzyme selected from the group consisting of a cytosolic malate dehydrogenase, a glycerol-3-phosphate dehydrogenase shuttle, an external NADH dehydrogenase, and an internal mitochondrial NADH dehydrogenase, wherein said at least two gene disruptions confers production of long chain alcohols in the mitochondrion of said organism.
Dependencies are inferred from the claim text.