Methods of reducing virus molecule levels
AssigneeAligos Therapeutics, Inc.
InventorsChia-Cheng Kao, Lawrence M. Blatt, Leonid Beigelman
Life of this patent
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Abstract
Methods of reducing levels of virus molecules and/or treating viral infections include contacting cells with an oligonucleotide inhibitor that targets a cellular host factor that is a target RNA or target protein involved in viral replication. A pharmaceutical composition can include such an oligonucleotide inhibitor in an amount effective for treating an infection, such as a hepatitis B infection or a respiratory virus infection, such as a coronavirus infection.
Claims16
A method of reducing a level of a hepatitis B virus (HBV) molecule produced by an infected cell, comprising:
- contacting the infected cell with an effective amount of an oligonucleotide inhibitor that targets a RPLP1 to thereby inhibit production of the RPLP1 by the infected cell and reduce the amount of the HBV virus molecule produced by the infected cell;
- wherein the infected cell produces an amount of at least one HBV molecule that the HBV utilizes for replication, wherein the HBV molecule is a viral protein, a viral DNA or a viral RNA.
A method of treating an HBV infection, comprising:
- administering a therapeutically effective amount of an oligonucleotide inhibitor to a subject in need thereof, wherein the oligonucleotide inhibitor targets a RPLP1 to thereby reduce production of the RPLP1 by infected cells of the subject.
Dependencies are inferred from the claim text.