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US 11,613,590 B2Granted
Binding proteins 1
AssigneesNucleus Therapeutics Pty. Ltd, Yale University
InventorsJames Campbell, Valentina Dubljevic, James Hansen, Zahra Rattray, Jiangbing Zhou
Life of this patent
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Abstract
The present disclosure relates to cell penetrating anti-DNA binding proteins. Compositions comprising these binding proteins may be may be useful for delivering agents to cells and treating diseases such as cancer.
Claims20
A cell penetrating anti-DNA binding protein having an antigen binding domain, wherein the antigen binding domain binds to DNA and comprises:
- a heavy chain variable region (VH) having a complementarity determining region (CDR) 1 as shown in SEQ ID NO:
- 1, a CDR2 as shown in SEQ ID NO:
- 3 and a CDR3 as shown in SEQ ID NO:
- 4;
- and
- a light chain variable region (VL) having a CDR1 as shown in SEQ ID NO:
- 6, a CDR2 as shown in SEQ ID NO:
- 7 and a CDR3 as shown in SEQ ID NO:
- 8.
6 more elements
Dependencies are inferred from the claim text.