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US 11,613,555 B2Granted
Methods for onapristone synthesis dehydration and deprotection
AssigneeContext Biopharma Inc.
InventorsUlf Tilstam, Stefan Proniuk, Ferry Brands
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Abstract
Methods and systems for making onapristone (ONA) using acidic hydrolysis and dehydration with sulfuric acid in an alcoholic solution are provided.
Claims22
A method of making onapristone comprising:
- reacting the compound of Formula I:
- with sulfuric acid in a solution comprising pyridine and a solvent to deprotect and dehydrate the compound of Formula I;
- maintaining the reaction temperature below about 60° C.;
- neutralizing the reaction with an inorganic base to form a solution;
- and
- extracting the compound of Formula II
- from the solution.
4 more elements
Dependencies are inferred from the claim text.