Substituted condensed thiophenes as modulators of sting

A compound of formula I:

• wherein:
• W is O or NH;
• R1 is selected from:
• (i) H;
• (ii) C3-6 cycloalkyl;
• (iii) 3-7 membered heterocyclyl optionally substituted with a group selected from:
• methyl;
• and
• —C(═O)OR, wherein R is selected from a C1-4 alkyl group, a 3-7 membered heterocyclyl, or a phenyl group;
• and
• (iv) linear or branched C1-4 alkyl optionally substituted with a group selected from:
• alkoxy;
• amino;
• —C(═O)N(R″)R′ wherein R′ and R″ are independently selected from H and C1-4 alkyl;
• —N(R″)C(═O)R′ wherein R′ and R″ are independently selected from H and C1-4 alkyl;
• —OC(═O)R, wherein R is selected from a C1-4 alkyl group, a 3-7 membered heterocyclyl, and a phenyl group;
• —OC(═O)O—C1-4 alkyl;
• —NHC(═O)O—C1-4 alkyl;
• —OC(═O)NR′R″ wherein R′ and R″ are independently selected from H and C1-4 alkyl;
• phenyl;
• —P(O)(OC1-4alkyl)2;
• 3-7 membered heterocyclyl optionally substituted with a group selected from methyl and oxo;
• and
• a naturally occurring amino acid, optionally N-substituted with a group selected from methyl, —C(O)—CH3 and boc;
• A1 is CRA or N;
• A2 is CRB or N;
• A3 is CRC or N;
• A4 is CRD or N;
• where no more than two of A1, A2, A3, and A4 may be N;
• one or two of RA, RB, RC, and RD, (if present) are selected from H, F, Cl, Br, Me, CF3, cyclopropyl, cyano, OMe, OEt, CH2OH, CH2OMe and OH;
• the remainder of RA, RB, RC, and RD, (if present) are H;
• Y is O, NH or CH2;
• RY is selected from:
• (a)
• wherein:
• Z1 is CRZ1 or N;
• Z2 is CRZ2 or N;
• Z4 is CRZ4 or N;
• Z5 is CRZ5 or N;
• where no more than two of Z1, Z2, Z4 and Z5 may be N;
• one or two of RZ1, RZ2, RZ4 and RZ5, (if present) are selected from H, F, Cl, Br, Me, OMe, cyano, CF3, CH2OH, CH2OMe, C2-4 alkenyl, and 5-membered heterocyclyl;
• the remainder of RZ1, RZ2, RZ4 and RZ5, (if present) are H;
• (b)
• where R12 is selected from H, F, Cl, Br, OMe, cyano and CF3;
• wherein each heterocyclyl comprises 1 or 2 heteroatoms selected from N and O;
• with the proviso that when A1 is CF;
• A2, A3 and A4 are CH;
• Y is O or NH;
• RY is RYA, where Z1, Z2, Z4 and Z5 are CH;
• R1 is not Et;
• and
• when A1 is CF;
• A2, A3 and A4 are CH;
• Y is NH;
• RY is RYA, where Z1 and Z5 are CH, one of Z2 and Z4 is CF, and the other of Z2 and Z4 is CH;
• R1 is not Et.