Heterocyclic compounds and uses as anticancer agents

A compound of Formula V:

• wherein
• X is CF2;
• R3 and R4 are independently hydrogen, C1-C6 alkyl, or —(CH2)mN(Ra)2, wherein m is one to 6;
• R5 is hydrogen or C1-C6 alkyl;
• R6 is hydrogen or C1-C6 alkyl;
• R7 is hydrogen or C1-C6 alkyl;
• R24 and R25 are independently selected from hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkenyl, C1-C6 alkynyl, hydroxy, cyano, nitro, —C(O)Ra, —OC(O)Ra, —C(O)ORa, —C(O)N(Ra)2, sulfonyl, sulfonylamino, aminosulfonyl, amino, and substituted amino;
• R26 is hydrogen, C1-C6 alkyl, or substituted C1-C6 alkyl, wherein C1-C6 alkyl is substituted with halogen, hydroxy, cyano, nitro, sulfonyl, sulfonylamino, aminosulfonyl, amino, or substituted amino;
• R22 is selected from hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkenyl, C1-C6 alkynyl, hydroxy, cyano, nitro, —C(O)Ra, —OC(O)Ra, —C(O)ORa, —C(O)N(Ra)2, sulfonyl, sulfonylamino, aminosulfonyl, amino, substituted amino acylamino, alkoxycarbonylamino, and aminocarbonylamino;
• R23 is selected from hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkenyl, C1-C6 alkynyl, hydroxy, cyano, nitro, —C(O)Ra, —OC(O)Ra, —C(O)ORa, —C(O)N(Ra)2, sulfonyl, sulfonylamino, aminosulfonyl, amino, substituted amino acylamino, alkoxycarbonylamino, and aminocarbonylamino;
• each Ra is independently hydrogen or C1-C6 alkyl;
• and
• Q is CH, CR23, or N;
• or a pharmaceutically acceptable salt thereof.