Recombinant adeno-associated virus capsids with enhanced human pancreatic tropism
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsKatja Pekrun, Mark A. Kay
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Abstract
The present invention relates to variant AAV capsid polypeptides, wherein the variant AAV capsid polypeptides exhibit increased transduction and/or tropism in human pancreatic tissue or human islets as compared non-variant parent capsid polypeptides.
Claims26
An adeno-associated virus (AAV) capsid polypeptide, wherein said AAV capsid polypeptide sequence is selected from the group consisting of AAV-10A1 (SEQ ID NO:1), AAV-10A3 (SEQ ID NO:2), AAV-10A4 (SEQ ID NO:3), AAV-10A5 (SEQ ID NO:4), AAV-18A1 (SEQ ID NO:5), AAV-10B1 (SEQ ID NO:6), AAV-10B3 (SEQ ID NO:7), AAV-10B5 (SEQ ID NO:8), AAV-10B6 (SEQ ID NO:9), AAV-10B7 (SEQ ID NO:10), AAV-18B2 (SEQ ID NO:12), and AAV-18B3 (SEQ ID NO:13).
An adeno-associated virus (AAV) vector comprising a nucleic acid sequence encoding an AAV capsid polypeptide, wherein said AAV capsid polypeptide sequence is selected from the group consisting of AAV-10A1 (SEQ ID NO:1), AAV-10A3 (SEQ ID NO:2), AAV-10A4 (SEQ ID NO:3), AAV-10A5 (SEQ ID NO:4), AAV-18A1 (SEQ ID NO:5), AAV-10B1 (SEQ ID NO:6), AAV-10B3 (SEQ ID NO:7), AAV-10B5 (SEQ ID NO:8), AAV-10B6 (SEQ ID NO:9), AAV-10B7 (SEQ ID NO:10), AAV-18B2 (SEQ ID NO:12), and AAV-18B3 (SEQ ID NO:13).
Dependencies are inferred from the claim text.