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US 11,608,324 B2Granted
Solid forms of fasoracetam
AssigneeThe Children's Hospital of Philadelphia
InventorsTom Leyssens, Richard Alan Couch, Michael Paul Rene Guillot, Bram Harmsen, Thomas R. Bailey, Martin Appelmans
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Abstract
The disclosure is directed to cocrystals of fasoracetam, including R-fasoracetam, and various coformers. Crystalline materials comprising fasoracetam, including R-fasoracetam, are also provided. The disclosure further includes pharmaceutical compositions and methods of treatment of the cocrystals and crystalline materials of the disclosure.
Claims18
A crystalline compound or cocrystal comprising fasoracetam and one of:
- (a) 4-aminobenzoic acid;
- (b) trimesic acid;
- (c) R-ibuprofen;
- (d) phloroglucinol;
- (e) methyl-3,4,5-trihydroxybenzoate;
- (f) ethyl gallate;
- (g) phthalic acid;
- (h) 6-hydroxy-2-naphthoic acid;
- (i) 4-nitrobenzoic acid;
- (j) 2-indole-3-acetic acid;
- and
- (k) urea.
9 more elements
Dependencies are inferred from the claim text.