Systems, methods, and devices for removing circulating tumor cells from blood
AssigneeOnco Filtration, Inc.
InventorsStephen S. Keaney, Katherine J. Soojian, Russell W. Bowden, Ilan K. Reich
Life of this patent
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Abstract
A crossflow filter includes a rigid cylindrical inner wall and a rigid cylindrical outer wall with an inelastic filter membrane positioned therebetween defining a retentate channel inside the filter membrane and a permeate channel outside the filter membrane. Further, the filter includes transition channels shaped and connected to the inner and outer walls to deliver a flow of fluid from an inlet port to the retentate channel and to capture flow flowing longitudinally along the cylindrical inner and outer walls from both the retentate and permeate channels to respective outlet ports.
Claims18
A crossflow filter, comprising:
- a rigid cylindrical inner wall and a rigid cylindrical outer wall with an inelastic filter membrane positioned therebetween defining a retentate channel disposed inward of the inelastic filter membrane and a permeate channel disposed outward of the inelastic filter membrane;
- a spherical inlet transition channel shaped and connected to said rigid cylindrical inner and outer walls to deliver a flow of fluid from an inlet port to the retentate channel;
- and
- outlet transition channels shaped and connected to said rigid cylindrical inner and outer walls to deliver flows of fluid flowing longitudinally along the rigid cylindrical inner and outer walls from both the retentate and permeate channels to respective outlet ports, wherein the rigid cylindrical inner wall and the rigid cylindrical outer wall have respective substantially constant internal diameters along entire lengths thereof.
A crossflow filter, comprising:
- a rigid cylindrical inner wall and a rigid cylindrical outer wall with an inelastic filter membrane positioned therebetween defining a retentate channel disposed inward of the inelastic filter membrane and a permeate channel disposed outward of the inelastic filter membrane;
- an inlet cap connected to the rigid cylindrical outer wall at a first end of the crossflow filter and having an inlet port arranged to introduce a flow of fluid into the crossflow filter, the inlet port having a central axis extending parallel to and coinciding with a central axis of the rigid cylindrical inner and outer walls;
- and
- transition channels shaped and connected to said rigid cylindrical inner and outer walls to deliver a flow of fluid from the inlet port to the retentate channel and to deliver flows of fluid flowing longitudinally along the rigid cylindrical inner and outer walls from both the retentate and permeate channels to respective outlet ports, wherein the transition channels are spherical in shape.
A crossflow filter, comprising:
- a cylindrical body including a rigid cylindrical inner wall and a rigid cylindrical outer wall;
- a first cap disposed on the cylindrical body at a first end of the crossflow filter;
- a second cap disposed on the cylindrical body at a second end of the crossflow filter;
- an inelastic filter membrane attached to either one or both of the first cap and the second cap, the inelastic filter membrane being positioned between the rigid cylindrical inner and outer walls to define a retentate channel disposed inward of the inelastic filter membrane and a permeate channel disposed outward of the inelastic filter membrane;
- and
- transition channels shaped and connected to said rigid cylindrical inner and outer walls to deliver a flow of fluid from an inlet port to the retentate channel and to deliver flows of fluid flowing longitudinally along the rigid cylindrical inner and outer walls from both the retentate and permeate channels to respective outlet ports.
Dependencies are inferred from the claim text.