Back to results
US 11,607,425 B2Granted
Kidney production method
AssigneesTakashi Yokoo, Bios Corporation
InventorsTakashi Yokoo, Shuichiro Yamanaka
Life of this patent
Estimating the term…
Abstract
The present invention provides a kidney production method including a step of tissue-specifically removing a metanephric mesenchyme of a metanephros of a non-human animal; a step of transplanting a human kidney precursor cell into the metanephros; and a step of advancing development of the metanephros, which is a step in which the transplanted human kidney precursor cell is differentiated and matured to form a part of the kidney.
Claims3
A kidney production method comprising:
- (i) tissue-specifically removing kidney precursor cells in a metanephric mesenchyme of a metanephros of a non-human animal;
- (ii) transplanting a human kidney precursor cell into the metanephros;
- and
- (iii) advancing development of the metanephros, wherein the transplanted human kidney precursor cell is differentiated and metanephric mesenchyme is regenerated,
- (iv) tissue-specifically removing kidney precursor cells in a ureteric bud of the metanephros;
- (v) transplanting a human kidney precursor cell into the metanephros;
- (vi) advancing development of the metanephros, wherein the transplanted kidney precursor cell is differentiated and ureteric bud is regenerated;
- and
- (vii) forming a kidney by advancing development of the metanephros,
- wherein (i) to (vii) are performed in an order of (i), (ii), (iii), (iv), (v), (vi), (vii) or in an order of (iv), (v), (vi), (i), (ii), (iii), (vii).
7 more elements
Dependencies are inferred from the claim text.