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AssigneeOisin Biotechnologies, Inc.
InventorsMatthew Rein Scholz, John David Lewis, Gary Charles Hudson
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Provided nucleic acid-based expression construct for the target cell-specific production of a therapeutic protein, such as a pro-apoptotic protein, within a target cell, including a target cell that is associated with aging, disease, or other condition, in particular a target cell that is a senescent cell or a cancer cell. Also provided are formulations and systems, including fusogenic lipid nanoparticle (LNP) formulations and systems, for the delivery of nucleic acid-based expression constructs as well as methods for making and using such nucleic acid-based expression constructs, formulations, and systems for reducing, preventing, and/or eliminating the growth and/or survival of a cell, such as a senescent cell and/or a cancer cell, which is associated with aging, disease, or other condition as well as methods for the treatment of aging, disease, or other conditions by the in vivo administration of a formulation, such as a fusogenic LPN formulation, comprising an expression construct for the target cell-specific production of a therapeutic protein, such as a pro-apoptotic protein, in a target cell that is associated with aging, disease, or other condition, in particular a target cell that is a senescent cell or a cancer cell.
A lipid-based nanoparticle (LNP) formulation for targeted production of a therapeutic protein within Hall target cells, the LNP formulation comprising:
A method of treating a condition in a subject in need thereof, the method comprising administering to the subject one or more lipid-based nanoparticle (LNP) formulations, the one or more LNP formulations comprising:
Dependencies are inferred from the claim text.