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US 11,603,492 B2Granted
Ultrabright lanthanide-doped nanoparticles
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsSteven Chu, Qian Liu, Yunxiang Zhang, Chunte Peng
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Abstract
An upconversion single molecule probe is provided that includes a core having a nanoparticle seed crystal, where the nanoparticle seed crystal is an upconversion seed crystal, a first shell enveloping the core, and a second shell enveloping the first shell.
Claims10
An upconversion nanoparticle, comprising:
- a) an optically inert core comprising a hexagonal-phase nanoparticle seed crystal;
- b) a hexagonal-phase first shell enveloping said core and including one or more rare earth ion doping species configured to provide upconversion;
- and
- c) an optically inert hexagonal-phase second shell enveloping said first shell.
1 more element
A method of fabricating an upconversion nanoparticle, comprising:
- a) synthesizing an optically inert hexagonal-phase core comprising a nanoparticle seed crystal;
- b) synthesizing a hexagonal-phase first shell on said core including one or more rare earth ion doping species configured to provide upconversion;
- and
- c) synthesizing an optically inert hexagonal-phase second shell on said first shell;
- wherein said nanoparticle seed crystal comprises NaREF4,
- wherein said RE is selected from the group consisting of Y, Gd, Lu, Yb, Er, Tm, Ho, Pr, Nd, Eu, Tb, Dy, Ce, Sm, and La.
3 more elements
Dependencies are inferred from the claim text.