Carboxamides as modulators of sodium channels

A compound of formula (I-A)

• or a pharmaceutically acceptable salt thereof, wherein:
• L is O, C(R)2, or a single bond;
• X5 is N or CR5;
• X6 is N or CR6;
• X7 is N or CR7;
• X9 is N or CR9;
• X10 is N or CR10;
• X11 is N or CR11;
• each R is independently H or C1-C6 alkyl;
• R2a is halo, OH, C1-C6 alkoxy, or C1-C6 haloalkoxy;
• R3a is H, halo, OH, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, or C1-C6 haloalkoxy;
• R4a is H, halo, OH, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, or C1-C6 haloalkoxy;
• R5, R6, and R7 are defined as follows:
• (i) R5, R6, and R7 are each independently H, halo, CN, OH, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylamino, or —W—(CH2)n—Rw;
• (ii) R5 is H, halo, CN, OH, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylamino, or —W—(CH2)nRw;
• and R6 and R7, together with the carbon atoms to which they are attached, form a ring of formula:
• or
• (iii) R5 and R6, together with the carbon atoms to which they are attached, form a ring of formula:
• and
• R7 is H, halo, CN, OH, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, or —W—(CH2)n—Rw;
• R8 is H or —O—(CH2)n—Rw;
• R9, R10, and R11 are each independently H, halo, CN, OH, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, or —W—(CH2)n—Rw;
• R12 and R13 are each independently H, halo, CN, OH, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, or —W—(CH2)n—Rw;
• or R12 and R13, together with the carbon atoms to which they are attached, form a ring of formula:
• Y1, Y2, Z1, and Z2 are each independently O or C(R14)2;
• each R14 is independently H, halo, C1-C4 alkyl, or C1-C4 haloalkyl;
• each W is independently O or a single bond;
• each Rw is independently 3-6 membered cycloalkyl, phenyl, or 5-6 membered heteroaryl, wherein said 3-6 membered cycloalkyl, phenyl, or 5-6 membered heteroaryl may be unsubstituted or may be substituted with 1-3 substituents selected from a group consisting of halo, C1-C6 alkyl, and C1-C6 haloalkyl;
• and
• n is 0 or 1;
• wherein when R8 is H, then at least one of X5, X6, and X7 is not N or CH;
• wherein no more than one of X5, X6, and X7 is N;
• wherein no more than one of X9, X10, and X11 is N.