Means and methods for treating herpesvirus infection
AssigneeHelmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
InventorsWolfgang Hammerschmidt, Reinhard Zeidler, Dagmar Pich
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Abstract
The present invention provides herpesviruses, such as EBV, which lack at least one viral miRNA. Such herpesviruses lacking at least one viral miRNA are advantageously not capable of packaging their genome into the capsid, thereby producing HVLPs, which are substantially free of their herpesvirus genome or the nucleic acid molecule encoding the proteinaceous part of the HVLP and viral miRNA. Such HVLPs may be used as vaccine.
Claims20
An Epstein-Barr VLP (EBVLP), comprising Epstein-Barr virus (EBV) proteins and lacking EBV miRNA, wherein said EBV miRNA is at least one being selected from the group consisting of miR-BHRF1-1, miR-BHRF1-2, miR-BHRF1-3, miR-BART1, miR-BART2, miR-BART3, miR-BART4, miR-BART5, and miR-BART15-.
Dependencies are inferred from the claim text.