Mass spectrometry
AssigneeUniversity of Warwick
InventorsPeter O'Connor, Maria A. Van Agthoven
Life of this patent
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Abstract
A method of carrying out mass spectrometry, comprising: using an electrostatic or electrodynamic ion trap to contain a plurality of ions, each ion having a mass to charge ratio, the ions having a first plurality of mass to charge ratios, each ion following a path within the electrostatic or electrodynamic ion trap having a radius; and for each of a second plurality of the mass to charge ratios: modulating the radii of the ions in a mass to charge ratio-dependent fashion dependent upon the mass to charge ratio; fragmenting the ions thus modulated in a radius-dependent fashion; and determining a mass spectrum of the ions.
Claims21
A method of carrying out mass spectrometry, comprising:
- using an electrostatic or electrodynamic ion trap to contain a plurality of ions, each ion having a mass to charge ratio, the plurality of ions having a first plurality of mass to charge ratios and a second plurality of mass to charge ratios, wherein each ion of the first plurality of mass to charge ratios follows a path within the electrostatic or electrodynamic ion trap having a radius;
- and
- wherein each of the second plurality of mass to charge ratios are discretely spaced apart within a continuous range and for each of the second plurality of mass to charge ratios the method comprises:
- modulating radii of the ions in a mass to charge ratio-dependent fashion dependent upon the mass to charge ratio;
- fragmenting the ions thus modulated in a radius-dependent fashion within the ion trap;
- and
- determining a mass spectrum of the ions after each fragmentation.
A mass spectrometry instrument, comprising an electrostatic or electrodynamic ion trap and a control circuit for the electrostatic or electrodynamic ion trap, the electrostatic or electrodynamic ion trap comprising electrodes comprising at least two axial trapping electrodes, a plurality of radial trapping electrodes and at least one excitation electrode, in which the control circuit is arranged so as to:
- apply voltages to each excitation electrode so as to contain, in use, a plurality of ions within a void defined by the electrodes, each ion following a path within the electrostatic or electrodynamic ion trap having a radius, the ions having a first plurality of mass to charge ratios;
- and
- a second plurality of mass to charge ratios, and wherein for each of a second plurality of the mass to charge ratios are discretely spaced apart within a continuous range and for each of the second plurality of mass to charge ratios the mass spectrometry instrument is configured to:
- modulate the radii of the ions dependent upon the mass to charge ratio;
- and
- wherein the instrument further comprises a fragmentation device arranged to fragment the ions of the second plurality of mass to charge ratios that were modulated in a radius-dependent fashion, wherein the ions are fragmented within the ion trap;
- and
- a mass determination device arranged to determine a mass spectrum of the ions after each fragmentation.
Dependencies are inferred from the claim text.