Biodosimetry panels and methods
AssigneesMeso Scale Technologies, LLC., The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
InventorsWilliam F. Blakely, Eli N. Glezer, John Kenten, Sudeep Kumar, Anu Mathew, Natalia I. Ossetrova, George Sigal
Life of this patent
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Abstract
The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
Claims10
A non-transitory computer readable medium having stored thereon a computer program which, when executed by a computer system operably connected to an assay system configured to measure, with a multiplexed immunoassay, levels of a plurality of biomarkers comprising salivary alpha-amylase, CD5, CD20, and Flt-3L in a sample from a human subject, causes the computer system to perform a method of identifying a radiation dose absorbed by the human subject, the method comprising:
- (a) fitting said measured levels of the salivary alpha-amylase, CD5, CD20, and Flt-3L to a response surface model as a function of radiation dose or time;
- (b) computing a cost function for combining said plurality of biomarkers;
- and
- (c) selecting a radiation dose that minimizes said cost function at a known time interval, thereby identifying the radiation dose absorbed by the human subject.
Dependencies are inferred from the claim text.