Methods and systems for analysis of mass spectrometry data
AssigneeImperial College of Science, Technology and Medicine
InventorsMarina Edelson-Averbukh, Leszek J. Frasinski, Taran Driver, David Klug, Jon P. Marangos
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Abstract
A method of analysing a structure of a composition of matter in a sample includes obtaining a data set comprising a plurality of spectra from the composition, from a first method of analysis, dividing each of the spectra into a plurality of bins, determining a control parameter or parameters indicative of synchronised fluctuations in signal intensity across some or all channels, resulting in universal correlation between said bins, and determining a partial covariance of different bins across the plurality of spectra using the control parameter to correct the correlation of intensity fluctuations between said bins.
Claims32
A method of analysing a structure of a composition of matter in a sample comprising:
- obtaining a data set comprising a plurality of spectra from the composition, from a first method of analysis;
- dividing each of the spectra into a plurality of bins;
- determining a control parameter or parameters indicative of synchronised fluctuations in signal intensity across some or all bins, resulting in universal correlation between said bins;
- determining a partial covariance of different bins across the plurality of spectra using the control parameter or parameters to correct the correlation of intensity fluctuations between said bins.
Dependencies are inferred from the claim text.