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US 11,599,994 B2Granted
System and methods for clear optimally matched panoramic channel technique for deep brain photonic interface
AssigneePurdue Research Foundation
InventorMeng Cui
Life of this patent
Estimating the term…
Abstract
An optical tissue imaging system includes a probe for insertion into a transparent cylindrical capillary. The capillary includes an internal cylindrical channel that extends along a central axis. The capillary is inserted into tissue of a subject, and the probe may rotate and translate within the capillary. The probe may include a mirror configured to reflect light to the tissue outside of the cylindrical capillary.
Claims20
An optical tissue imaging system comprising:
- a transparent cylindrical capillary for insertion into a brain tissue, the transparent cylindrical capillary having an internal cylindrical channel that extends along a central axis of the transparent cylindrical capillary;
- and
- a probe comprising a mirror configured to reflect light to the brain tissue adjacent to a cylindrical wall of the transparent cylindrical capillary, the probe being rotatable within the transparent cylindrical capillary and movable along the central axis of the transparent cylindrical capillary;
- wherein the mirror is positioned at a first end of the probe,
- wherein the mirror is configured to reflect light received at a second end of the probe to the brain tissue, and
- wherein the mirror is configured to direct light reflected or emitted from the brain tissue to the second end of the probe.
3 more elements
A method, comprising:
- inserting a transparent cylindrical capillary into a brain tissue of a mammal;
- attaching a probe to a rotary stage;
- positioning the probe in line of sight of a camera;
- spinning the probe;
- capturing images of the probe in a plurality of positions specified by the spinning;
- identifying a rotational axis of the rotary stage based on the images;
- aligning the probe with the rotational axis;
- inserting the probe into an opening of the transparent cylindrical capillary, the probe comprising a mirror;
- emitting a light through the probe and onto the mirror to cause the light to be directed onto the brain tissue located radially outward from the transparent cylindrical capillary;
- rotating the mirror;
- translating the mirror axially along the transparent cylindrical capillary;
- and
- capturing light reflected or emitted onto the mirror from the brain tissue at various locations specified by the rotating and translating.
10 more elements
An optical tissue imaging system comprising:
- a transparent cylindrical capillary for insertion into a brain tissue, the transparent cylindrical capillary having an internal cylindrical channel that extends along a central axis of the transparent cylindrical capillary;
- and
- a probe comprising a mirror configured to reflect light to the brain tissue adjacent to a cylindrical wall of the transparent cylindrical capillary, the probe being rotatable within the transparent cylindrical capillary and movable along the central axis of the transparent cylindrical capillary;
- wherein the mirror reflects the light at an angle between 30 and 150 degrees relative to the central axis of the transparent cylindrical capillary.
1 more element
An optical tissue imaging system comprising:
- a transparent cylindrical capillary for insertion into a brain tissue, the transparent cylindrical capillary having an internal cylindrical channel that extends along a central axis of the transparent cylindrical capillary;
- and
- a probe comprising a mirror configured to reflect light to the brain tissue adjacent to a cylindrical wall of the transparent cylindrical capillary, the probe being rotatable within the transparent cylindrical capillary and movable along the central axis of the transparent cylindrical capillary;
- wherein the mirror is positioned at a first end of the probe, the probe further comprising a relay lens and an objective lens positioned in between the relay lens and mirror.
1 more element
Dependencies are inferred from the claim text.