Widefield three-dimensional microscopy with a quantum entanglement light source

A method for three-dimensional quantum (3DQ) imaging, comprising:

• generating a first set of photons and a second set of photons, wherein each of the photons in the first set is quantum entangled with a corresponding photon in the second set;
• directing the second set of photons toward a sample and simultaneously directing the first set of photons toward a first two-dimensional (2D) detector without the first set of photons being incident on the sample;
• detecting, from the sample, a plurality of photons at a second 2D detector, wherein the plurality of photons is produced in response to absorption and reemission, scattering, or reflection of the second set of photons by or from the sample;
• analyzing detections from the first and second 2D detectors to determine coincidence information;
• and
• determining one or more characteristics associated with at least a three-dimensional (3D) section of the sample based on collective detections at the first and the second 2D detectors, wherein the detections at the first 2D detector correspond to two spatial dimensions of the 3D section of the sample and the detections at the second 2D detector correspond to at least a third dimension of the 3D section of the sample.