Light sheet microscope and method for imaging an object

A light sheet microscope, comprising:

• an object slide configured to hold an object on a slide plane;
• an optical illumination system including an illumination objective configured to illuminate a first object plane of the object with a light sheet, the first object plane being oblique relative to the slide plane;
• and
• an optical detection system including a detection objective and an image sensor device, the image sensor device being configured to define a first image plane which is orthogonal to an optical axis of the detection objective and to define a second image plane which is tilted relative to the first image plane, the detection objective being configured to image a focal plane onto the first image plane and to image a second object plane of the object onto the second image plane, the focal plane being coincident with the first object plane illuminated with the light sheet, and the second object plane being parallel to or coincident with the slide plane.