Biomarkers and methods for detection of seizures and epilepsy

A method of treating a seizure disorder in a patient, the method comprising:

• obtaining a blood plasma or blood serum sample from the patient;
• measuring or detecting the concentration of thymus and activation-regulated chemokine (TARC) in the blood plasma or blood serum sample via at least one selected from the group of enzyme-linked immunoassay (ELISA), Indirect ELISA, Sandwich ELISA, Competitive Elisa, Multiple and Portable (M&P) ELISA, and combinations thereof;
• measuring or detecting the concentration of tumor necrosis factor alpha (TNF-α) in the blood plasma or blood serum sample via at least one selected from the group of enzyme-linked immunoassay (ELISA), Indirect ELISA, Sandwich ELISA, Competitive Elisa, Multiple and Portable (M&P) ELISA, and combinations thereof;
• comparing concentrations of TARC and TNF-α to normal control concentrations of TARC and TNF-α, respectively;
• determining at least one of the following:
• i) the concentration of TARC in the blood plasma or blood serum sample obtained from the patient is increased compared to the normal control concentration of TARC;
• and ii) the concentration ratio of TNF-α to TARC in the blood plasma or blood serum sample obtained from the patient is decreased compared to the normal control concentration ratio of TNF-α to TARC;
• diagnosing the seizure disorder in the patient;
• and
• administering a therapy for epilepsy to the patient, wherein the therapy for epilepsy is a therapeutically effective dose of an anti-epileptic compound selected from the group consisting of phenytoin, fosphenytoin, midazolam, pregabalin, brivaracetam, perampanel, rufinamide, lurasidone HCl, carbamazepine, clobazam, clonazepam, diazepam, divalproex, eslicarbazepine acetate, ethosuxemide, ezogabine, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, lorazepam, oxcarbazepine, phenobarbital, primidone, tiagabine, topiramate, valproic acid, zonisamide, cannabis based drugs and pharmaceutically acceptable salts, prodrugs, and derivatives thereof.