Methods of diagnosis and treatment of Alzheimer's Disease
AssigneeThe Regents of the University of California
InventorsXinhua Zhan, Boryana S. Stamova-Kiossepacheva, Frank R. Sharp
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Abstract
Provided are methods of mitigating, reversing or eliminating in a subject one or more symptoms associated with cognitive impairment associated with amyloid deposits in the brain (e.g., olfactory dysfunction as a risk factor of dementia, mild cognitive impairment, Alzheimer's Disease) by detecting and targeting gram negative bacteria in the brain.
Claims21
A method of determining whether gram-negative bacteria molecules are co-localized with amyloid plaques in a subject exhibiting one or more symptoms associated with cognitive impairment associated with amyloid deposits in the brain, comprising determining in a central nervous system (CNS) sample from the subject the presence of gram-negative bacteria;
- and positively identifying the presence of gram-negative bacteria in the sample as indicative of gram-negative bacteria molecules co-localized with amyloid plaques in the subject, wherein positively identifying the presence of gram-negative bacteria in the sample comprises detecting the presence of E. coli K99 pili protein and the level of E. coli K99 pili protein is significantly greater in the sample from the subject exhibiting one or more symptoms associated with cognitive impairment associated with amyloid deposits in the brain than in a control CNS sample.
Dependencies are inferred from the claim text.