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US 11,598,769 B2Granted
Oligomerized protein-polymer conjugates
AssigneeMassachusetts Institute of Technology
InventorsBradley David Olsen, Hadley Sikes Johnson, Eric Alexander Miller, Justin Paloni
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Abstract
The present disclosure relates to protein-polymer conjugates comprising an engineered binding oligomer protein and a polymer for detection of a ligand of interest, methods, compositions and kits thereof.
Claims18
A protein-polymer conjugate comprising an oligomer of an engineered binding protein linked to a polymer,
- wherein the engineered binding protein is a Sso7d protein, a Sac7d protein, an engineered coiled-coil protein, or an antibody variable domain,
- wherein the protein-polymer conjugate self-assembles into a lamellar nanostructure, and
- wherein:
- (i) the protein-polymer conjugate forms a thin film that comprises at least 2-fold more binding sites in an area of the protein-polymer conjugate compared to a monolayer of the engineered binding protein of the same size as the area of the protein-polymer conjugate;
- and/or
- (ii) the unit spacing between repeating domains of the protein-polymer conjugates is less than 30 nm.
3 more elements
Dependencies are inferred from the claim text.