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US 11,598,759 B2Granted
Sensors and sensor arrays for detection of analytes
AssigneeIcagen, Inc.
InventorsBenjamin P. Warner, Chang-Tai Hsieh, Emilia Solomon, Lori Peterson, Douglas Krafte, Nathan Zahler
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Abstract
Methods, apparatus and compositions are described for the measurement of metal and/or metalloid elements, including selenium in samples. More specifically, the present disclosure provides a sensor and/or array of sensors to measure metal and/or metalloid analytes, e.g., sensor and/or array of sensors having a chelator molecule, the chelator molecule including a peptide.
Claims13
A method for measuring a metal and/or metalloid element in a sample, the method comprising:
- combining a sample containing the metal and/or metalloid element and a sensor or array of sensors, the sensor or array of sensors comprising a chelator molecule and a solid support and being capable of concentrating the metal and/or metalloid element from the sample and, measuring the sample of metal and/or metalloid element on the sensor or array of sensors;
- wherein the chelator molecule comprises a peptide, the peptide having a general formula of:
- F1CZ1Z2CZ3Z4Z5CF2
- wherein:
- F1 and F2 are each independently a phenylalanine derivative having the structure:
- wherein X is a halogen;
- C is a cysteine amino acid;
- and
- Z1, Z2, Z3, Z4, and Z5 are each independently an amino acid;
- or
- wherein the chelator molecule comprises a peptide, the peptide having a general formula of:
- Y1CRX1SC
- wherein:
- C is the amino acid cystine;
- R is the amino acid arginine;
- S is the amino acid serine;
- X1 is the amino acid Q or T;
- Y1 is a tyrosine derivative having the structure:
- and
- Y and Z are a halogen or one of Y and Z is a halogen and one of Y and Z is hydrogen.
17 more elements
Dependencies are inferred from the claim text.