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US 11,598,720 B2Granted
Computer-implemented method and system for spectroscopic analysis of biological material
AssigneeThe Automation Partnership (Cambridge) Limited
InventorsAdrian Stacey, Christian Grimm, Marek Hoehse, Thomas Regen, Angus Woodhams
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Abstract
A computer-implemented method for spectroscopic analysis of biological material is provided that includes analyzing samples of biological material from a plurality of sources, and delivering samples of biological material to at least one flow cell for spectroscopy, and determining whether the spectroscopic analysis for each sample of the plurality of samples is or is predicted to be ambiguous in that it is affected by at least two non-discriminable factors. If such a determination is made, a disambiguating step can be performed.
Claims15
A computer-implemented method for spectroscopic analysis of biological material, the method including an analysis step comprising:
- taking, by a liquid router, a plurality of samples of biological material from a plurality of sources, wherein each sample of the plurality of samples is taken from a source of the plurality of sources;
- delivering, by the liquid router, the plurality of samples of biological material to at least one flow cell for spectroscopy;
- performing, by at least one spectrometer connected to the at least one flow cell, the spectroscopic analysis of the plurality of samples of biological material;
- determining whether the spectroscopic analysis for each sample of the plurality of samples is or is predicted to be ambiguous in that it is affected by at least two non-discriminable factors being temporally correlated;
- and
- upon determining that the spectroscopic analysis for a given sample of the plurality of samples of biological material is or is predicted to be ambiguous, performing a first disambiguating step or a second disambiguating step to break the correlation of the at least two non-discriminable factors, the disambiguating step,
- wherein the first disambiguating step comprises taking, by the liquid router, the given sample of biological material from the at least one flow cell to a manipulation station;
- manipulating, at the manipulation station, the given sample of biological material in order to impact the spectroscopic analysis;
- delivering, by the liquid router, the given manipulated sample of biological material from the manipulation station to the at least one flow cell;
- and
- performing, by the at least one spectrometer, the spectroscopic analysis of the given manipulated sample of biological material;
- wherein the second disambiguating step comprises taking, by the liquid router, a secondary sample of biological material from the same source of the given sample for which the spectroscopic analysis is or is predicted to be ambiguous;
- routing, by the liquid router, the secondary sample of biological material from the source to a manipulation station;
- manipulating, at the manipulation station, the secondary sample of biological material in order to impact the spectroscopic analysis;
- delivering, by the liquid router, the manipulated secondary sample of biological material from the manipulation station to the at least one flow cell;
- and
- performing, by the at least one spectrometer, the spectroscopic analysis of the manipulated secondary sample of biological material;
- wherein information obtained via the disambiguating step with the secondary sample is used for the spectroscopic analysis of the given sample.
15 more elements
A system for spectroscopic analysis of biological material, the system comprising:
- a plurality of sources of biological material;
- a liquid router;
- at least one flow cell;
- a manipulation station;
- and
- an interface device;
- wherein:
- the interface device is configured to receive instructions for automatically controlling operations of the system;
- the liquid router is configured to take a plurality of samples of biological material from the plurality of sources, wherein each sample of the plurality of samples is taken from a source of the plurality of sources, and to deliver the plurality of samples of biological material to the at least one flow cell;
- the at least one flow cell is configured to be connected to at least one spectrometer;
- and
- when a spectroscopic analysis of a given sample of the plurality of samples of biological material by the at least one spectrometer is or is predicted to be ambiguous in that the spectroscopic analysis is affected by at least two non-discriminable factors being temporally correlated,
- wherein the liquid router is configured in a first or second configuration,
- wherein in the first configuration the liquid router is configured to:
- route the given sample of biological material from the at least one flow cell to the manipulation station, wherein the manipulation station is configured so that the given sample of biological material is manipulated in order to impact the spectroscopic analysis;
- and
- deliver the given manipulated sample of biological material from the manipulation station to the at least one flow cell;
- wherein in the second configuration the liquid router is configured to:
- take a secondary sample of biological material from the same source of the given sample for which the spectroscopic analysis is or is predicted to be ambiguous;
- route the secondary sample of biological material from the source to a manipulation station, wherein the manipulation station is configured so that the secondary sample of biological material is manipulated in order to impact the spectroscopic analysis;
- and
- deliver the manipulated secondary sample of biological material from the manipulation station to the at least one flow cell, wherein information obtained with the secondary sample is used for the spectroscopic analysis of the given sample.
19 more elements
Dependencies are inferred from the claim text.