Peptides that block transmission of orthotospoviruses and methods of using the same
AssigneeBoard of Trustees of the University of Arkansas
InventorsIoannis Tzanetakis, Jing Zhou
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Abstract
Orthotospovirus virions travel through the thrips foregut and enter midgut epithelial cells through the interaction between virus glycoproteins and cellular receptors with several protein motifs thought to be involved in the interaction. Single, double and triple mutant polypeptides in the soybean vein necrosis virus (SVNV)/Neohydatothrips variabilis system are provided herein and several are shown to block viral transmission from the thrips to the soybean plants. Methods for inhibiting viral transmission using these polypeptides or constructs comprising polynucleotides encoding peptides are also provided herein.
Claims20
A composition comprising;
- a) at least three polypeptides comprising each of the amino acid sequences of SEQ ID NOs:
- 4(NASIAGDHEVSQE), 5(NASIRADHEVSQE), and 6 (NASIRGAHEVSQE), respectively, or
- b) a polypeptide comprising the amino acid sequence of
- SEQ ID NO:
- 3 (NASIAAAHEVSQE).
Dependencies are inferred from the claim text.