Combination therapy of lymphoma
AssigneeThe Trustees of Columbia University in the City of New York
InventorsJennifer Effie Amengual, Jennifer Lue, Owen A. O'Connor
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Abstract
The present disclosure provides for methods and compositions for treating cancer. A subject having lymphoma is administered an EZH2 inhibitor and an HDAC inhibitor. The combination of the EZH2 inhibitor and the HDAC inhibitor produces a synergistic effect on the cancer compared to the effect of the EZH2 inhibitor or the HDAC inhibitor alone.
Claims15
A method of treating lymphoma in a subject in need thereof, the method comprising administering an Enhancer of Zeste Homolog 2 (EZH2) inhibitor and a histone deacetyltransferase (HDAC) inhibitor to the subject, wherein the EZH2 inhibitor is tazemetostat and the HDAC inhibitor is belinostat.
A method of treating lymphoma cells in vitro, comprising contacting the lymphoma cells with an EZH2 inhibitor and an HDAC inhibitor, wherein the EZH2 inhibitor is tazemetostat and the HDAC inhibitor is belinostat.
Dependencies are inferred from the claim text.