Targeted inhibition using engineered oligonucleotides
AssigneemiRecule, Inc.
InventorsRobert Place, Anthony Saleh, Tishan Williams
Life of this patent
Estimating the term…
Abstract
Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide.
Claims16
An engineered microRNA (miRNA) or salt thereof, wherein the engineered miRNA or salt thereof comprises SEQ ID NO:
- 88.
An engineered passenger oligonucleotide or salt thereof, wherein the engineered passenger oligonucleotide or salt thereof comprises SEQ ID NO:
- 96, and wherein the engineered passenger oligonucleotide or salt thereof is no more than 20 nucleotides in length.
A nucleic acid construct comprising a first strand comprising SEQ ID NO:
- 88 and a second strand comprising SEQ ID NO:
- 96.
Dependencies are inferred from the claim text.