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US 11,597,925 B2Granted
Peptide nucleic acid conjugates
AssigneeVentana Medical Systems, Inc.
InventorsAoune Barhoumi, Rui Hong
Life of this patent
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Abstract
The disclosure is directed to conjugates, e.g. PNA conjugates, as well as methods of employing the conjugates for detecting one or more targets in a biological sample, e.g. a tissue sample.
Claims12
A peptide nucleic acid conjugate having the structure of Formula (IC):
- wherein
- ‘Specific binding entity’ is selected from the group consisting of an antibody, an antibody fragment, a drug/antibody complex, and a nucleic acid;
- ‘Linker’ is a branched or unbranched, linear or cyclic, substituted or unsubstituted, saturated or unsaturated, group having between 2 and 80 carbon atoms, and optionally having one or more heteroatoms selected from O, N, or S;
- ‘PNA’ is a peptide nucleic acid sequence;
- X is selected from the group consisting of biotin, an enzyme, a chromogen, a fluorophore, a hapten, and a mass spectrometry tag;
- Y is a branched or unbranched, linear or cyclic, substituted or unsubstituted, saturated or unsaturated group having between 1 and 12 carbon atoms and optionally having one or more O, N, or S heteroatoms;
- m is an integer ranging from 1 to 6;
- z is 1;
- and
- n is an integer ranging from 1 to 12.
7 more elements
Dependencies are inferred from the claim text.