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US 11,597,911 B2Granted
Expansion of populations of T cells by the use of modified serum free media
AssigneesLife Technologies Corporation, The Trustees of the University of Pennsylvania
InventorsAngel M. Varela-Rohena, Melanie B. Andolina, James L. Riley, Andrew Medvec
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Abstract
This invention relates, inter alia, to compositions of low serum or serum free media and methods for the expansion of T cell populations and methods for using such populations of cells. In some aspects, the invention relates to compositions and methods for the selective expansion of T cell subpopulations.
Claims12
A method for culturing a population of cells comprising one or more T cells comprising:
- (a) incubating T cells from a subject with serum-free media comprising glucose and galactose, wherein the glucose:galactose ratio ranges from 10:90 to 90:10;
- (b) growing the culture of T cells for at least 10 days;
- and optionally
- (c) harvesting the T cells from the culture.
1 more element
Dependencies are inferred from the claim text.