US 11,597,767 B2 · Monoclonal antibodies that bind TRBV9 and methods for using same for inhibiting the T cell receptor for treatment

Abstract

The invention relates to monoclonal antibodies which specifically bind to the TRBV9 family of human T-cell receptors. The invention also relates to a nucleic acid which codes for said antibody or for an antigen-binding fragment thereof, to an expression vector, to a method for producing the antibody, and to the use of said antibody for treating diseases or disorders associated with the family of human T-cell receptors. The invention is directed towards producing antibodies that can be used for eliminating T-cells carrying T-cell receptors of the TRBV9 family, in particular for treating ankylosing spondylitis, coeliac disease, and blood cancers, in the pathogenesis of which T-cell receptors of the TRBV9 family are involved.

Claims13

Dependent claims

A monoclonal antibody or antigen-binding fragment thereof that specifically binds to the TRBV9 (T Cell Receptor Beta Variable 9) family beta chain region of human T cell receptor, comprising:

1) a heavy chain variable domain comprising HCDR1, HCDR2 and HCDR3, where
the HCDR 1 comprises the amino acid sequence of SEQ ID NO:
1,
the HCDR 2 comprises the amino acid sequence of SEQ ID NO:
2,
the HCDR 3 comprises the amino acid sequence selected from the group of SEQ ID NO:
3, SEQ ID NO:
4, SEQ ID NO:
5, and SEQ ID NO:
6;
and
2) a light chain variable domain comprising LCDR1, LCDR2 and LCDR3, where
the LCDR 1 comprises the amino acid sequence of SEQ ID NO:
7,
the LCDR 2 comprises the amino acid sequence of SEQ ID NO:
8, and
the LCDR 3 comprises the amino acid sequence of SEQ ID NO:
9.

15 more elements

Dependencies are inferred from the claim text.

Monoclonal antibodies that bind TRBV9 and methods for using same for inhibiting the T cell receptor for treatment

Life of this patent

Monoclonal antibodies that bind TRBV9 and methods for using same for inhibiting the T cell receptor for treatment

Life of this patent

Abstract

Claims13