TCR and peptides
AssigneesOspedale San Raffaele S.R.L., Fondazione Centro San Raffaele
InventorsMaria Chiara Bonini, Eliana Ruggiero, Zulma Irene Magnani, Luca Aldo Edoardo Vago, Attilio Bondanza, Fabio Ciceri
Life of this patent
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Abstract
TCR AND PEPTIDES A T-cell receptor (TCR), which binds to a Wilms tumour 1 protein (WT1) peptide when presented by a major histocompatibility complex (MHC).
Claims41
A T-cell receptor (TCR), which binds to a Wilms tumour 1 protein (WT1) peptide when presented by a major histocompatibility complex (MHC), wherein the TCR comprises the following CDR sequences:
- (SEQ ID NO:
- 1)
- (i) CDR1α-KALYS,
- (SEQ ID NO:
- 2)
- CDR2α-LLKGGEQ,
- (SEQ ID NO:
- 3)
- CDR3α-CGTAWINDYKLSF,
- (SEQ ID NO:
- 6)
- CDR1β-SGHDY,
- (SEQ ID NO:
- 7)
- CDR2β-FNNNVP,
- and
- (SEQ ID NO:
- 8)
- CDR3β-CASRKTGGYSNQPQHF,
An isolated polynucleotide comprising a nucleotide sequence encoding an α chain of a T-cell receptor (TCR), and/or a nucleotide sequence encoding a β chain of a TCR, wherein the TCR binds to a Wilms tumour 1 protein (WT1) peptide when presented by a major histocompatibility complex (MHC), and wherein the TCR comprises the following CDR sequences:
- (SEQ ID NO:
- 1)
- CDR1α - KALYS,
- (SEQ ID NO:
- 2)
- CDR2α - LLKGGEQ,
- (SEQ ID NO:
- 3)
- CDR3α - CGTAWINDYKLSF,
- (SEQ ID NO:
- 6)
- CDR1β - SGHDY,
- (SEQ ID NO:
- 7)
- CDR2β - FNNNVP, and
- (SEQ ID NO:
- 8)
- CDR3β - CASRKTGGYSNQPQHF
A polypeptide encoded by a polynucleotide comprising a nucleotide sequence encoding an α chain of a T-cell receptor (TCR), and/or a nucleotide sequence encoding a β chain of a TCR, wherein the TCR binds to a Wilms tumour 1 protein (WT1) peptide when presented by a major histocompatibility complex (MHC), and wherein the TCR comprises the following CDR sequences:
- (SEQ ID NO:
- 1)
- CDR1α - KALYS,
- (SEQ ID NO:
- 2)
- CDR2α - LLKGGEQ,
- (SEQ ID NO:
- 3)
- CDR3α - CGTAWINDYKLSF,
- (SEQ ID NO:
- 6)
- CDR1β - SGHDY,
- (SEQ ID NO:
- 7)
- CDR2β - FNNNVP, and
- (SEQ ID NO:
- 8)
- CDR3β - CASRKTGGYSNQPQHF
Dependencies are inferred from the claim text.