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US 11,597,753 B2Granted
Activatable IL2 composition and methods of use
AssigneeImmune Targeting, Inc.
InventorsTao Yue, Yang Wang
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Abstract
The present invention includes proteins, nucleic acids and methods of making and using an activatable interleukin-2 (aIL2) comprising an Interleukin-2 (aIL2) fusion protein comprising: an Interleukin-2 (IL2) wild-type or mutein; a first cleavable linker; an interleukin-2 receptor binding region (IL2RB), and a half-life extender, such as an antibody Fc region, wherein cleavage of the cleavable linker releases the IL2 from the interleukin-2 receptor beta binding region.
Claims17
An activatable Interleukin-2 (aIL-2) fusion protein comprising:
- an Interleukin-2 (IL-2) mutein comprising an R81E and L85T mutation;
- a first cleavable linker connected to the IL-2 mutein;
- an interleukin-2 receptor beta (IL-2R beta) binding region connected to the first cleavable linker;
- and
- a half-life extender connected to the IL-2 or the IL-2 receptor beta,
- wherein cleavage of the first cleavable linker releases the IL-2 mutein from the IL2-R beta, wherein the IL-2 mutein has increased binding affinity for IL-2R beta at pH 7.4 and retains binding to the IL-2R beta at pH 6.4.
3 more elements
Dependencies are inferred from the claim text.