β-modified phosphoric acid compound precursor, β-modified phosphoric acid compound, reaction inhibitor and medicine containing the same, and method for inhibiting reaction

A β-modified phosphoric acid compound precursor, comprising

• a structure represented by the following formula 4A,
• [Chemical Formula 4A]
• wherein A1 represents —SR1, —S—S—R1, —SeR1, or —X, where X is a halogen selected from the group consisting of fluoro, chloro, bromo, and iodo;
• R1 represents hydrogen, an alkyl group having 1 to 20 carbon atoms, an aryl group having 1 to 20 carbon atoms, or an alkenyl group having 1 to 20 carbon atoms;
• R3 is an unsaturated fatty acid selected from the group consisting of arachidonic acid, linoleic acid, and linolenic acid;
• and R4 is a saturated fatty acid selected from the group consisting of stearic acid, and palmitic acid.

A reaction inhibitor for a phosphorylation reaction, comprising a β-modified phosphoric acid compound precursor,

• wherein the β-modified phosphoric acid compound precursor is a nucleoside derivative represented by the following formula 2A or a nucleic acid having the nucleoside derivative represented by the following formula 2A at the 3′-end thereof, and inhibits a reaction of a DNA polymerase,
• [Chemical Formula 2A]
• wherein A1 represents —SR1, —S—S—R1, —SeR1, or —X, where X is a halogen selected from the group consisting of fluoro, chloro, bromo, and iodo;
• R1 represents hydrogen, an alkyl group having 1 to 20 carbon atoms, an aryl group having 1 to 20 carbon atoms, or an alkenyl group having 1 to 20 carbon atoms;
• L3 represents a monophosphate group, diphosphate group, or triphosphate group represented by the following formula 2D,
• [Chemical Formula 2D]
• where n is an integer of 1 to 3, Z1 represents a hydroxyl group, or a methyl ester, ethyl ester, isopropyl ester, n-butyl ester, benzyl ester, or phenyl ester of glycine, alanine, valine, leucine, phenylalanine, tryptophan, methionine, or proline, Z2 represents an alkyl group having 1 to 4 carbon atoms, a halogen, or a phenyl group, and when n is 2 or more, each Z1 may be the same as or different from each other Z1;
• and
• B represents a base selected from the group consisting of adeninyl, guaninyl, cytosinyl, thyminyl, uracilyl, N-methyladeninyl, N-benzoyladeninyl, 2-methylthioadeninyl, 2-aminoadeninyl, 7-methylguaninyl, N-isobutyrylguaninyl, 5-fluorocytosinyl, 5-bromocytosinyl, 5-methylcytosinyl, 4-N-methylcytosinyl, 4-N,N-dimethylcytosinyl, 5-fluorouracilyl, 5-bromouracilyl, 5-chlorouracilyl, and 5,6-dihydrouracilyl;
• and the symbol * represents a bond to be bonded to a phosphate group by phosphorylation, and defines bonding of hydrogen or a substituent before the phosphorylation, wherein the substituent is not a phosphate group.