Tropomyosin receptor kinase inhibitor, preparation method therefor and use thereof
AssigneeJiangsu Vcare PharmaTech Co., Ltd.
InventorsYong Wu, Wenbin Zhou, Yanchun Gong, Yaoxiang Yue, Jie Deng, Yongqiang Liu
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Abstract
Disclosed in the present invention are a pyrazolo [1,5-a]pyrimidine derivative having a structure of formula (I), a pharmaceutical composition comprising the compound of formula (I), and use of the compound in the preparation of a medicament for preventing or treating diseases associated with tropomyosin receptor kinases, in particular for preventing or treating cancers associated with tropomyosin receptor kinases. Each substituent in formula (I) has the same definition as that in the description.
Claims13
A compound represented by formula (I), stereoisomer thereof, or pharmaceutically acceptable salt thereof:
- wherein R1 is selected from H, C1-C8 alkyl, C3-C8 cycloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, —COR5, —SO2R5, and —SOR5, and optionally further substituted with one or more substituents selected from deuterium, halogen, hydroxyl, cyano, nitro, —NR6R8, —NR6COR7, —COR7, —SO2R7, —SOR7, C1-C8 alkyl, C3-C8 cycloalkyl, C1-C8 alkoxy, and a 4-10 membered heterocyclic group;
- R2 and R4 are each independently selected from H, C1-C8 alkyl, C3-C8 cycloalkyl, C2-C8 alkenyl, and C2-C8 alkynyl, and optionally further substituted with one or more substituents selected from deuterium, halogen, hydroxyl, cyano, nitro, —NR6R8, —NR6COR5, —COR5, —SO2R5, —SOR5, C1-C8 alkyl, C3-C8 cycloalkyl, C1-C8 alkoxy, and a 4-10 membered heterocyclic group;
- R5 and R7 are each independently selected from H, C1-C8 alkyl, C3-C8 cycloalkyl, and —NR8;
- R6 and R8 are each independently selected from H, C1-C8 alkyl, and C3-C8 cycloalkyl;
- Y is —(CH2)n— or —O(CH2)n—;
- n is 0, 1, 2 or 3;
- alternatively, any two of R1, R2, and R4 independently form a C3-C8 cycloalkyl group or a 4-10 membered heterocyclic group;
- R3 is selected from H, deuterium, halogen, cyano, nitro, C1-C8 alkyl, C3-C8 cycloalkyl, and C1-C8 alkoxy;
- and
- X is CH or N.
A compound, stereoisomer thereof or pharmaceutically acceptable salt thereof, wherein the compound has a structural formula selected from the following:
A compound, stereoisomer thereof or pharmaceutically acceptable salt thereof, wherein the compound has a structural formula selected from the following:
Dependencies are inferred from the claim text.