URAT1 inhibitor for promoting uric acid excretion
AssigneeJiangsu Atom Bioscience and Pharmaceutical Co., Ltd.
InventorsDongfang Shi, Jianghua Zhu, Jie Gu, Xi Cheng, Yan Yang, He Zhou, Pengfei Li, Fan Wu
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Abstract
The present invention belongs to the field of medicinal chemistry. Specifically disclosed is a class of URAT1 inhibitors for promoting uric acid excretion, which are compounds as represented by the structure of formula (I) or pharmaceutically acceptable salts thereof. Experiments show that the compounds provided by the present invention have a very good inhibitory effect on the transport of uric acid by hURAT1 in HEK293 transfected cells, and that such compounds have a good application prospect in the treatment of hyperuricemia or gout.
Claims10
A compound, a (4-Hydroxyphenyl) (diazole) ketone derivative, as represented by the structure of formula (I-1) or pharmaceutically acceptable salts thereof
- wherein,
- A is a non-aromatic six-membered ring;
- Y is carbonyl or;
- R1 is one or more selected from the group consisting of hydrogen, deuterium, hydroxy, halogen, nitro, amino, cyano, C1-5 alkyl, substituted C1-5 alkyl, substituted C1-3 amino, C1-3 alkoxy, substituted C1-3 alkoxy and C1-5 alkylthio;
- R2 is one or more selected from the group consisting of hydrogen, deuterium, hydroxy, halogen, nitro, amino, cyano, C1-4 alkyl, substituted C1-3 alkyl, C2-3 alkenyl, C2-3 alkynyl, substituted C1-3 amino, C1-5 alkoxy, substituted C1-5 alkoxy and C1-5 alkylthio;
- R3 is C1-4 alkyl, substituted C1-4 alkyl or C3-4 cycloalkyl;
- m is an integer from 0 to 3;
- n is an integer from 1 to 3.
Dependencies are inferred from the claim text.