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US 11,597,715 B2Granted
Inhibitors of dihydroceramide desaturase for treating disease
AssigneeCentaurus Therapeutics
InventorsDonna L. Romero, Jeremy Blitzer
Life of this patent
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Abstract
Disclosed herein are dihydroceramide desaturase 1 (Des1) inhibitor compounds and compositions, which are useful in the treatment of diseases, such as metabolic disorders, where inhibition of Des1 is expected to be therapeutic to a patient. Methods of inhibition of Des1 activity in a human or animal subject are also provided.
Claims13
A compound of structural Formula II
- or a salt thereof, wherein:
- W is chosen from —NH— and —O—;
- X is N;
- Y is chosen from CH and N;
- R5 is chosen from alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, (aryl)alkyl, (heteroaryl)alkyl, (aryl)aryl, (heteroaryl)aryl, (aryl)heteroaryl, and (heteroaryl)heteroaryl, and is optionally substituted with 1, 2, or 3 R6 groups;
- each R6 is independently chosen from alkoxy, alkyl, amino, carboxy, cyano, halo, haloalkoxy, haloalkyl, and hydroxy;
- and
- n is chosen from 1 and 2.
5 more elements
Dependencies are inferred from the claim text.