Therapeutic DNP derivatives and methods using same

A method of ameliorating a disease or disorder in a subject in need thereof,

• wherein the disease or disorder is at least one selected from the group consisting of hypertriglyceridemia, fatty liver, and insulin resistance,
• the method comprising administering to the subject a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof:
• wherein:
• R1, R2, and R3 are H;
• X1 is OR4;
• R4 is independently selected from the group consisting of —C1-C3 alkyl-(C6-C10 aryl), —C1-C3 alkyl-(C3-C6 cycloalkyl), and —C1-C3 alkyl-(C5-C10 heteroaryl);
• and
• wherein the aryl, cycloalkyl, or heteroaryl is independently optionally substituted by at least one substituent selected from the group consisting of C1-6 alkyl, C1-6 alkoxy, halogen, acetamido, —CN, —NH2, —OH, —NH(CH3), —N(CH3)2, —CF3, —CH2CF3, —OCF3, —OCH2CF3, and nitro.