Back to results
US 11,596,944 B2Granted
Microfluidic devices with bubble diversion
AssigneeQuantumdx Group Limited
InventorsHojjat Madadi, Thomas Michael Willshare, Jonathan O'Halloran, Philip Thomas Scully, Paul Marshall, Eduardo Boada
Life of this patent
Estimating the term…
Abstract
A microfluidics device has one or more bubble diversion regions. Problems associated with the generation of air bubbles are avoided in a microfluidics device such as a cartridge, for use with a point of care (POC) diagnostics device, the cartridge being able to carry out downstream processing such as polymerase chain reaction (PCR) and/or nucleic acid capture. The bubble diversion region has a lower flow resistance than the flow resistance of an area of interest.
Claims20
A microfluidics device comprising:
- a micro-channel configured to provide a fluid flow path, comprising:
- at least one area of interest for binding, capturing, imaging, or viewing within the micro-channel, and
- a bubble diversion region adjacent to the at least one area of interest, the bubble diversion region having a greater height than the height of the at least one area of interest and a lower flow resistance than the flow resistance of the at least one area of interest,
- a first substrate having a first surface and a second surface opposite the first surface,
- a second substrate, wherein the second substrate is overlaid the first substrate,
- wherein the micro-channel comprises a groove in the first substrate, the micro-channel extending from the groove in the first surface of the first substrate to the second surface of the first substrate through a first aperture in the first substrate, and from the second surface of the first substrate to the first surface of the first substrate through a second aperture in the first substrate,
- wherein the second surface of the first substrate comprises a plug receiving section, and
- wherein at least a part of a geometry of the bubble diversion area is provided on the second surface of the first substrate.
5 more elements
Dependencies are inferred from the claim text.