Back to results
US 11,596,919 B2Granted
Row-independent oligonucleotide synthesis
OwnerBruce Erickson, Marshall Henryinventors
Life of this patent
Estimating the term…
Abstract
Apparatuses and a method for plate-based oligonucleotide synthesis are disclosed. In one example, an apparatus used in oligonucleotide synthesis includes a machined block to receive a commercially-available synthesis plate. A keeper is used to apply pressure to the commercially-available synthesis plate, and a sealing element is used to seal the commercially-available synthesis plate to the machined block. Other methods and apparatuses are disclosed.
Claims7
An apparatus comprising:
- a synthesis plate having a plurality of rows, each row of the plurality of rows comprising a plurality of wells and each well of the plurality of wells comprising a waste tip on a bottom of the synthesis plate;
- a drain block located beneath the synthesis plate, the drain block comprising a sealing element having a receiving feature including elongated openings extending along a plane of the receiving feature, each one of the elongated openings is located below a respective row of the plurality of rows of the synthesis plate;
- a gasket disposed between the synthesis plate and the drain block, the gasket having a set of holes, wherein the waste tip of the each well of the plurality of wells is fitted into a respective hole of the set of holes of the gasket;
- and
- a keeper located on top of the synthesis plate, the keeper fastened to the drain block by a mechanical fastener, the mechanical fasteners applying pressure to the synthesis plate and the gasket, thereby forming a seal around each of the plurality of rows and each of the plurality of wells of the synthesis plate.
2 more elements
Dependencies are inferred from the claim text.