Biomimetically designed modular microfluidic-based capillaries and lymphatic units for kidney and liver dialysis systems, organ bio-reactors and bio-artificial organ support systems

A modular microfluidic dialysis system, the system comprising:

• a plurality of microfluidic units, the plurality of microfluidic units configured to enable dialysis of blood, tissue, or plasma, the plurality of microfluidic units arranged in modular configuration for enabling scalability, the modular configuration of the system configured such that about 20-40 microfluidic units form a microfluidic construct, the modular configuration of the system further configured such that about 5 microfluidic constructs form a microfluidic module, the microfluidic module configured to position inside a microfluidic housing, the plurality of microfluidic units at least partially fabricated from polydimethylsiloxane, the plurality of microfluidic units comprising:
• a blood microfluidic chip and a dialysate microfluidic chip, the blood microfluidic chip configured to carry blood, tissue, or plasma, the dialysate microfluidic chip configured to carry a fluid, the blood microfluidic chip and the dialysate microfluidic chip comprising a plurality of micro-pumps, the plurality of micro-pumps configured to pump the blood, tissue, or plasma to and from the blood microfluidic chip, the plurality of micro-pumps further configured to pump the fluid to and from the dialysate microfluidic chip, the blood microfluidic chip and the dialysate microfluidic chip further comprising a plurality of micro-valves, the plurality of micro-valves configured to regulate flow of the fluid and the blood, tissue, or plasma, the blood microfluidic chip and the dialysate microfluidic chip further comprising a plurality of micro-channels, the plurality of microchannels defined by a topography having a substantially microvasculature configuration, the plurality of micro-channels further defined by varying widths, the plurality of microchannels configured to carry the blood, tissue, or plasma to and from the blood microfluidic chip, the plurality of micro-channels further configured to carry the fluid to and from the dialysate microfluidic chip;
• and
• at least two basic semipermeable membranes, the at least two basic semipermeable membranes disposed between the blood microfluidic chip and the dialysate microfluidic chip, the at least two basic semipermeable membranes configured to form a permeable barrier between the fluid and the blood, tissue, or plasma, the at least two basic semipermeable membranes further configured to enable passage of toxins and water from the blood, tissue, or plasma in the blood microfluidic chip to the fluid in the dialysate microfluidic chip;
• a plurality of microfluidic regenerating units, the plurality of microfluidic regenerating units configured to at least partially filter contaminated fluid received from the dialysate microfluidic chip, the plurality of microfluidic regenerating units further configured to return regenerated fluid to the dialysate microfluidic chip;
• and
• a data transmission portion, the data transmission portion configured to enable real time monitoring of physiological parameters of body and mechanical parameters of the system.