Partial deformation maps for reconstructing motion-affected treatment dose

A radiation treatment delivery system comprising:

• a memory to store information;
• and
• a processing device, operatively coupled to the memory, the processing device to:
• identify a treatment planning image of a target subject, the treatment planning image comprising the information associated with an arrangement of structures within the target subject;
• generate, based on the information, a set of reference data associated with the target subject, the reference data indicating a plurality of positions of the target subject;
• generate a first target-subject-specific model based on the reference data;
• apply the first target-subject-specific model to the treatment planning image to generate a transformed treatment planning image corresponding to a first position of the plurality of positions;
• compare the transformed treatment planning image to a reference image;
• based on the comparing, modify one or more hyper-parameters of the first target-subject-specific model to generate a second target-subject-specific model corresponding to a second position of the plurality of positions;
• and
• control a radiation treatment delivery device based on the second target-subject-specific model to deliver a radiation treatment to the target subject.

A non-transitory, computer-readable storage medium comprising instructions, which when executed by a processing device, cause the processing device to:

• identify a treatment planning image of a target subject, the treatment planning image comprising information associated with an arrangement of structures within the target subject;
• generate, based on the information, a set of reference data associated with the target subject, the reference data indicating a plurality of positions of the target subject;
• generate a first target-subject-specific model based on the reference data;
• apply, by the processing device, the first target-subject-specific model to the treatment planning image to generate a transformed treatment planning image corresponding to a first position of the plurality of positions;
• compare the transformed treatment planning image to a reference image;
• based on the comparing, modify one or more hyper-parameters of the first target-subject-specific model to generate a second target-subject-specific model corresponding to a second position of the plurality of positions;
• and
• control a radiation treatment delivery device based on the second target-subject-specific model to deliver a radiation treatment to the target subject.