Controlled outgassing of hyberbarically loaded materials for the delivery of oxygen and other therapeutic gases in biomedical applications
AssigneeThe Johns Hopkins University
InventorsColin Cook, Warren Grayson
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Abstract
Devices and methods for delivering oxygen and other therapeutic gases to a target, such as a tissue, a tissue-engineered construct, and a wound, in a controlled and sustained manner are disclosed.
Claims6
A scaffold comprising a polymeric material having embedded in a continuous phase thereof one or more microtanks, the one or more microtanks having a hollow core-shell morphology having an exterior comprising a polymeric material selected from the group consisting of polyethylene terephthalate (PET), polycaprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA), poly(lactic acid) (PLA), and poly(glycolic acid) (PGA), and an interior comprising a material selected from the group consisting of polyvinyl alcohol (PVOH), ethylene vinyl alcohol (EVOH), a phenolic resin, and porous silica, wherein the interior of the core-shell comprises a void having a shape of a microbubble, a microballoon, a microsphere, or a microtube, wherein the void comprises one or more gases at a hyperbaric pressure and has a spherical shape having a diameter ranging from about 1 nanometer to about 1000 micrometers.
Dependencies are inferred from the claim text.